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Acpharis Scientists’ Research Featured in the Proceedings of the National Academy of Sciences

In the August 16 issue of the Proceedings of the National Academy of Sciences, research done by Acpahris scientists was highlighted as “In This Issue.”

In the paper, Kozakov et. al. explore the druggability of protein-protein interactions, a hot new class of targets that are validated by the large amount of data being produced by systems biology efforts showing their impact in a large number of disease pathways. By applying computational solvent mapping, the authors show that hot spots for the binding of fragment-sized molecules can be found in the interfaces, even on unliganded proteins. An interface with several hot spots clustered together is amenable to the binding of  drug-like molecules and these hot spots found on the unliganded proteind correspond to the binding of ligands discovered for these interfaces.

In PNAS, Read the Highlight

In PNAS, Read the Article