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Acpharis Scientists Present Short Course at Structure-Based Drug Design Conference

Acpharis’s President, CTO, and other staff members jointly presented a short course at CHI's Structure-Based Drug Design conference entitled "Identification of Druggable Sites for Protein-Protein Interaction Targets". The course gave an overview of protein-protein interactions and their feasibility as drug targets. After a general overview, the participants explored both protein-protein docking, using PIPER, and computational solvent mapping to explore these interfaces.

The instruction was accompanied by a wonderful dinner.

Acpharis awarded NIH STTR Grant: “High-throughput portable software for fragment-based drug design”

Acpharis announced today that it has been awarded an NIH STTR grant application entitled “High-throughput portable software for fragment-based drug design”. The NIH STTR program is intended to stimulate a partnership of ideas and technologies between innovative small business concerns (SBCs) and non-profit research institutions through Federally-funded research or research and development (R/R&D).

Computational Solvent Mapping Used to Predict Binding Mode of Anti-cancer agent

In the January 18 issue of PNAS, Cencic et. al. reported the results of an  ultra-high-throughput screening for inhibitors of the translation initiation complex eIF4F.  This screening resulted in the identification of a compound that prevents the formation of this complex from its components eIF4E and eIF4G.  Blocking this interaction sensitizes many cancer types to the apoptotic response to DNA damage.